Can I afford this home?

I am a single woman living in Washington state, looking to buy my first home. I found one that I fell in love with, costing $440,000.

I make about $100,000 Gross pay. I take home about $5000 per month after taxes.

I have no debt. My current rent is about $1600 per month.

I think I can put about 15-20% down.

Can I afford this home comfortably? How much do people typically leave in their bank after down payment?

I still want to be able to save for the future. Any advice appreciated!