Cloud Backups (Backblaze B2 Buckets specifically) - How are you doing it?

I've been an OMV user for a while now and have used Duplicati in a container to encrypt/backup to Backblaze.

I've had issues here and there over the years with it and often wanted to leave - but didn't know any other options. I'm exploring (seriously) other options now as I recently built out a new OMV server and want to 'start fresh' with something that can encrypt/backup to Backblaze relatively easily.

Duplicati has always felt a bit half-baked, and with issues in upgrades and what not I've never really trusted it. Some of my backups are 600+gb in size and from what I've read in larger backups there are issues. In small tests I did (10mb) it has worked, but for larger backups - well, I haven't tested it. When trusting family photos/videos, I want to have something I know will work. But at the same time, I'm also looking for maybe a little easier to use? Something I could setup a cron job for and just have it encrypt/backup to backblaze through OMV's interface?

I'm curious what others might be using to accomplish similar. Any advice is helpful!