Farming runs and Tradeoff perk questions

I’m at the point where I’m trying to coin farm tier 1, max 6600. (I’m currently researching 4th perk choice). I’ve already selected the 1.8 coin and 50/50 damage perks. My question is: Are these options all round killers? I’m running the natural “early game” blender.. all the orbs, everything is gold boxed except the big 4… I’m scared of the other “tradeoff perks”. I still have other labs I need to boost before getting into the tradeoff perk labs. What tradeoff perks are more “neutral” than “harmful”? Thanks!